Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis
نویسندگان
چکیده
The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, precursor of squamous-cell carcinoma.
منابع مشابه
Use of Lesion Response Rate in Actinic Keratosis Trials
Complete patient clearance is often required by regulatory agencies for the approval of treatments for actinic keratosis (AK). However, an increasing number of clinicians have challenged the use of this measure in clinical practice and its interpretation. It has been argued that complete patient clearance often underestimates the clinical benefit of a drug and is influenced by a number of key c...
متن کاملSunlight (actinic) keratosis: an update.
L. FELLER, R.A.G. KHAMMISSA, N.H. WooD, Y. JADWAT, R. MEYERoV, J. LEMMER Department of Periodontology and oral Medicine, School of Dentistry, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa; * School of Dentistry, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa Professor Emeritus: University of Witwatersrand, Johannesburg, Universi...
متن کاملOptimal treatment of actinic keratosis
License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be f...
متن کاملA Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity.
Actinic keratosis (AK) lesions are surrounded by field cancerization (areas of subclinical, non-visible sun damage). Existing AK grading tools rely on AK counts, which are not reproducible. An Actinic Keratosis Field Assessment Scale (AK-FAS) for grading the severity of AK/field was developed. Standardized photographs of patients representing the full range of AK severity were collected. Six in...
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ژورنال
عنوان ژورنال: The New England Journal of Medicine
سال: 2021
ISSN: ['0028-4793', '1533-4406']
DOI: https://doi.org/10.1056/nejmoa2024040